Introduction
The Macintosh IIsi Uses a 50-Pin SCSI Drive, that doesn't need to be terminated while in single configuration.
Tools
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            Now lift these two clips, and slowly pivot the case up. 
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            You can now seperate the top of the computer from the rest of the machine. 
 
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            The Macintosh IIsi's hard drive is located ajacent to the ram and floppy drive. 
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            Start by pushing these two tabs out, and lifting the drive up. 
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            Then, flip the drive over, and remove the connection cables. 
 
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            The hard drive: A Quantum ProDrive LPS, made in 1990, and surprisingly, it still works! 
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            This drive has an 80MB capacity, not very large by today's standards, but not bad way back then... 
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            Believe it or not, hard drive construction hasn't changed much in the last 20 years. Other than a few new interfaces, the form factor, 3.5" width and 4-Pin 12V/5V power connector has stayed the same. 
 
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To reassemble your device, follow these instructions in reverse order.