Singles
2018 Uruguay Open
Champion	Guido Pella
Runner-up	Carlos Berlocq
Score	6–3, 3–6, 6–1

Pablo Cuevas was the defending champion but lost in the first round to Mario Vilella Martínez.

Guido Pella won the title after defeating Carlos Berlocq 6–3, 3–6, 6–1 in the final.

Seeds

Draw

Finals

	Semifinals							Final
		Mario Vilella Martínez	1	4
		Carlos Berlocq	6	6
									Carlos Berlocq	3	6	1
								2	Guido Pella	6	3	6
		Pedro Sousa	6	3	4
	2	Guido Pella	2	6	6

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	P Cuevas	2	2
		M Vilella Martínez	6	6					M Vilella Martínez	6	77
	WC	T Seyboth Wild	2	6	2			Q	D Kuzmanov	2	63
	Q	D Kuzmanov	6	4	6											M Vilella Martínez	6	6
	WC	C Taberner	67	65											WC	M Cuevas	3	4
	WC	M Cuevas	79	77				WC	M Cuevas	4	7	7
	Q	F Díaz Acosta	2	5				5	T Monteiro	6	5	5
	5	T Monteiro	6	7																			M Vilella Martínez	1	4
	4	P Andújar	6	6																			C Berlocq	6	6
		J Domingues	0	3				4	P Andújar	64	5
	Alt	F Argüello	5	6	6			Alt	F Argüello	77	7
		A De Greef	7	3	3										Alt	F Argüello	3	6	5
		F Bagnis	2	0												C Berlocq	6	3	7
		C Berlocq	6	6					C Berlocq	3	6	7
	Q	F Coria	6	0	62			7	P Lorenzi	6	2	5
	7	P Lorenzi	3	6	77

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	6	H Dellien	6	6
	WC	F Llanes	2	3				6	H Dellien	5	5
		D Gimeno Traver	6	6					D Gimeno Traver	7	7
		G Elias	4	1												D Gimeno Traver	6	5	1
		G Clezar	1	2												P Sousa	3	7	6
		P Sousa	6	6					P Sousa	6	6
	Q	Juan Ignacio Galarza	6	5	3			3	G Andreozzi	1	3
	3	G Andreozzi	1	7	6																		P Sousa	6	3	4
	8	JI Londero	7	1	2																	2	G Pella	2	6	6
		P Cachin	5	6	6				P Cachin	1	3
		L Giustino	6	6					L Giustino	6	6
		T Bellucci	3	3												L Giustino	1	2r
		F Gaio	65	5											2	G Pella	6	3
		P Krstin	77	7					P Krstin	6	3	5
		R Cid Subervi	4	1				2	G Pella	1	6	7
	2	G Pella	6	6

References

• Main draw
• Qualifying draw