Nickname

• Babe Adams (1882–1968), American Major League Baseball pitcher
• Babe Barna (1917–1972), American Major League Baseball left fielder
• Woolf Barnato (1895–1948), British financier and racing driver
• Babe Borton (1888–1954), Major League Baseball first baseman
• John H. Brown Jr. (1891–1963), American football player and United States Navy vice admiral
• Don Chandler (1934–2011), American National Football League punter and placekicker
• Babe Clark (1889–1974), American football player
• Babe Dahlgren (1912–1996), American Major League Baseball infielder who replaced Lou Gehrig
• Babe Didrikson Zaharias (1911–1956), American multi-sport female athlete, most noted as a golfer
• Babe Dye (1898–1962), Canadian professional ice hockey forward
• Babe Ellison (1895–1955), Major League Baseball player
• Babe Frump (1901–1979), American offensive guard in the National Football League
• Babe Herman (1903–1987), American Major League Baseball right fielder
• Jacquelyn Kelley (1926–1988), member of the All-American Girls Professional Baseball League
• Babe Laufenberg (born 1959), American retired National Football League quarterback
• Howard "Babe" Lydecker (1911–1969), half of the Lydecker brothers, a movie special effects team
• Babe London (1901–1980), American actress and comedian
• Babe Martin (1920–2013), American Major League Baseball outfielder
• Babe McCarthy (1923–1975), American professional and collegiate basketball coach
• Babe Paley (1915–1978), American socialite and style icon
• Babe Parilli (1930–2017), American quarterback in the National, American, and Canadian Football Leagues
• Babe Parnell (1901–1982), American football player
• Babe Pinelli (1895–1984), American third baseman and umpire in Major League Baseball
• Babe Pratt (1916–1988), Canadian ice hockey defenseman
• Babe Russin (1911–1984), American jazz saxophonist
• Babe Ruth (1895–1948), American Major League baseball player
• Babe Scheuer (1913–1997), American football player
• Babe Siebert (1904–1939), Canadian National Hockey League player
• Emmett "Babe" Wallace (1909–2006), American singer, composer, actor
• Babe Ziegenhorn (1918–1970), American professional basketball player

Stage or ring name

• Oliver Hardy (1892–1957), American comic actor sometimes billed as "Babe Hardy" early in his career
• Babe the Farmer's Daughter, a ring name of professional wrestler and businessperson Ursula Hayden (1966-2022)

Surname

• Jerome Babe (1837–1893), American inventor and miner
• Thomas Babe (1941–2000), American playwright

Fictional characters

• Babe the Blue Ox, companion of the mythical lumberjack Paul Bunyan
• Babe, the title character of the Dick King-Smith book The Sheep-Pig
• Babe Carano, from Game Shakers
• Babe Carey, a character in the American soap opera All My Children

Films

• Babe (film), a 1995 Australian film based on the book The Sheep-Pig
  • Babe: Pig in the City, the 1998 sequel
• The Babe, a 1992 film about baseball player Babe Ruth starring John Goodman

Music

Other uses in arts and entertainment

• Babe (comics), a comic book by artist/writer John Byrne