Bezborodko (Cyrillic: Безбородько or Безбородко) is a gender-neutral Ukrainian surname that may refer to the following notable people:
- Alexander Bezborodko (1747–1799), Grand Chancellor of Russian Empire
 - Alexander Kushelev-Bezborodko (1800–1855), Russian nobleman and politician
 - Denys Bezborodko (born 1994), Ukrainian football forward
 - Grigory Kushelev-Bezborodko (1832–1870), Russian writer, publisher and philanthropist, son of Nikolai
 - Nikolai Alexandrovich Kushelev-Bezborodko (1834–1862), Russian art collector, son of Nikolai
 
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