Demaine or de Maine is a surname. Notable people with the surname include:
- Erik Demaine (born 1981), Canadian computer scientist, son of Martin
 - Martin Demaine (born 1942), American artist and computer scientist, father of Erik
 - Mike Demaine (1948–2013), Australian footballer (Australian rules)
 - Paul A. D. de Maine (1924–1999), American computer scientist
 - Robert deMaine (born 1969), American cellist
 - William Demaine (1859–1939), Australian politician
 - David Demaine (born 1942), English footballer
 
See also
- Demaine, Saskatchewan, hamlet in Saskatchewan, Canada
 
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