Duke is a masculine given name, also used as a nickname or stage name. Notable people with the name include:
- Duke Aiona (born 1955), American politician
- Duke Cunningham (born 1941), American fighter pilot and politician
- Duke Dawson (born 1996), American football player
- Duke Droese (born 1968), American wrestler
- Duke Dumont (born 1981), English DJ
- Duke Ejiofor (born 1995), American football player
- Duke Ellington (1899-1974), American jazz musician
- Duke Ihenacho (born 1989), American National Football League player
- Duke Kahanamoku (1890–1968), Hawaiian swimmer and surfer
- Duke McKenzie (born 1963), British retired boxer
- Duke Pearson (1932-1980), American jazz musician
- Duke Powell (born 1955), American paramedic and politician
- Duke Riley, American artist
- Duke Riley (American football) (born 1994), American football player
- Duke Snider (1926-2011), American baseball player
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