FRS may also refer to:
Government and politics
- Facility Registry System, a centrally managed Environmental Protection Agency database that identifies places of environmental interest in the United States
 - Family Resources Survey, a survey to collect information on the incomes and circumstances of households in Great Britain
 - Federal Reserve System, the central bank of the United States
 - Fire and Rescue Service, an organization that provides predominantly emergency firefighting services for a specific geographic area
 - Fisheries Research Services, a now-defunct agency of the Executive agencies of the Scottish Government
 - Forum of Social Republicans (French: Forum des républicains sociaux), now the Christian Democratic Party, a French political party
 
Science
- Fellow of the Royal Society, an award and fellowship granted by the Royal Society of London to individuals the society judges to have made a "substantial contribution to the improvement of natural knowledge"
 - Filtered Rayleigh scattering, a diagnostic technique which measures velocity, temperature, and pressure
 - Forward recoil scattering, an ion beam analysis technique in materials science to obtain elemental concentration depth profiles in thin films
 - Fragment separator, an ion-optical device used to focus and separate products from the collision of relativistic ion beams with thin targets
 - Framingham Risk Score, a gender-specific algorithm used to estimate the 10-year cardiovascular risk of an individual.
 - Free radical scavenger, a synonym for antioxidant
 - Free radical substitution, a substitution reaction involving free radicals as a reactive intermediate
 
Technology
- Family Radio Service, an improved walkie-talkie radio system in the United States
 - File Replication Service, a Microsoft Windows Server service for distributing shared files and Group Policy objects
 - Frame Relay Switch, a standardized wide-area network technology that specifies the physical and data link layers of digital telecommunications channels using a packet switching methodology
 - Freely redistributable software, software that anyone is free to redistribute
 - Functional requirement Specification, defines a function of a system or its components
 - Facial recognition system, a computer application capable of identifying or verifying a person from a digital image or a video frame from a video source
 
Transportation
- Ffestiniog Railway Society, a 1 ft 11 1⁄2 in (597 mm) narrow gauge heritage railway, located in Gwynedd, Wales
 - Flandre Air, (ICAO: FRS) was a French regional airline
 - Förde Reederei Seetouristik, a German shipping company
 - Forsinard railway station, in northern Scotland
 - Franconia–Springfield station, Amtrak station code FRS
 - Full-rigged ship, a sailing vessel's sail plan with three or more masts, all of them square-rigged
 - Mundo Maya International Airport, (IATA: FRS, formerly Flores International Airport) in Flores, Guatemala
 - Scion FR-S, an automobile
 
Other uses
- Fixed repeating schedule, a production scheduling methodology
 - Fleet Replacement Squadron, a unit of the United States Navy and Marine Corps
 - Free Record Shop, a Dutch retailer
 - Frontier Regional School, in South Deerfield, Massachusetts, United States
 - Saterland Frisian language, last living dialect of the East Frisian language
 - East Frisian Low Saxon, Frisian-Saxon dialect of East Frisia
 
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