First Avenue or 1st Avenue may refer to:

Music venue

• First Avenue (nightclub), a music venue in downtown Minneapolis

Streets

• 1st Avenue (Chicago), a major thoroughfare of the city
• 1st Avenue (Seattle), a street in the city's downtown
• First Avenue (Manhattan), a major thoroughfare in New York City

See also

• First Avenue Records, a former record label
• First Avenue South Bridge in Seattle
• First Avenue station (PAAC) on the Port Authority of Allegheny County's light rail network
• First Avenue Public School, an elementary school in Ottawa, Ontario, Canada
• First Avenue (BMT Canarsie Line), a subway station
• List of highways numbered 1
• First Street (disambiguation)