Frederick or Fred Lewis may refer to:
Sportspeople
- Carl Lewis (Frederick Carlton Lewis, born 1961), American track athlete and Olympic medalist
 - Fred Lewis (born 1980), American baseball player
 - Fred Lewis (1880s outfielder) (1858–1945), 19th-century American baseball player
 - Fred Lewis (basketball, born 1921) (1921–1994), college basketball coach
 - Fred Lewis (footballer, born 1886) (1886–1949), English footballer for Stoke
 - Fred Lewis (footballer, born 1923) (1923–1975), English footballer for Chelsea and Colchester United
 - Fred Lewis (handball) (born 1947), American handball player
 - Freddie Lewis (born 1943), American basketball player who played in the National Basketball Association and American Basketball Association
 - Frederick Pea (born 1969), American basketball player formerly known as Fred Lewis
 - Jack Lewis (footballer, born 1948), born Frederick John Lewis, Wales under-23 international footballer
 
Others
- Frederick, Prince of Wales (1707–1751), who was sometimes known by his full name Frederick Louis (or Lewis)
 - Sir Frederick Orr-Lewis (1860–1921), Canadian businessman
 - Fred Ewing Lewis (1865–1949), American politician
 - R. Fred Lewis (born 1947), Chief Justice of the Florida Supreme Court
 - Frederick M. Lewis, known for his contribution to the Mayo–Lewis equation in polymer chemistry
 - Frederick Lewis, 1st Baron Essendon (1870–1944), British shipping magnate
 - Fred P. Lewis, American meteorologist
 - Frederick Christian Lewis (1779–1856), English etcher, engraver and painter
 
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