Hertwig is a German surname. Notable people with the surname include:
- Benjamin Hertwig, Canadian poet
- Craig Hertwig (1952–2012), American football player
- Michael Hertwig (born 1960), German football player and manager
- Oscar Hertwig (1849–1922), German zoologist
- Paula Hertwig (1889–1983), German biologist, politician
- Richard Hertwig (1850–1937), German zoologist
See also
- Hertwig's sheath, a proliferation of epithelial cells
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