Itis may refer to:
Healthcare
- Inflammation
 - Postprandial somnolence (colloquially "the itis"), a state of drowsiness or lassitude following a meal
 
Information systems
- Integrated Taxonomic Information System, a partnership designed to provide consistent and reliable information on the taxonomy of biological species
 - Integrated Transport Information System, a traffic management system in Klang Valley, Malaysia
 
Places
- Itis (Swedish name of Iitti), a municipality in Päijänne Tavastia, Finland
 
Other uses
- Itis shopping centre, a shopping centre in the district of Itäkeskus in East Helsinki, Finland
 - "The Itis" (The Boondocks), the tenth episode of the Adult Swim animated television series, The Boondocks
 
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