Jayne is used both as a surname and as a given name.
Surname
- Billy Jayne, American television and film actor
 - Caroline Furness Jayne (1873–1909), American ethnologist
 - Erika Jayne, American dance/club music performer
 - Francis Jayne (1845–1921), British bishop and academic
 - Horace Jayne (1859–1913), American biologist, zoologist, professor at the University of Pennsylvania and author
 - Ira W. Jayne (1882–1961), American judge
 - Jennifer Jayne (1931–2006), English film and television actress
 - Joey Jayne, Democratic Party member of the Montana House of Representatives
 - Joseph Lee Jayne (1863–1928), rear admiral in the United States Navy, veteran of the Spanish–American War and World War I
 - Keith Jayne (born 1960), a British television actor
 - Mark Jayne, American wrestler
 - Mitchell F. Jayne (1928–2010), emcee and upright bass player in The Dillards bluegrass band
 - Randy Jayne (born 1944), managing partner at Heidrick & Struggles
 - Robert Jayne (born 1973), American actor
 - Roland Everett Jayne (1886–1937), Methodist clergyman and biographer
 - Richard Jayne (1930-2022), Historian and prisoner of war
 - Sam Jayne, vocalist/guitarist of indie band Love as Laughter, formerly of Lync.
 - Silas Carter Jayne (1907–1987), implicated in the 1955 murder of three young boys in Chicago
 - William Jayne (1826–1916), Abraham Lincoln’s personal physician, first governor of the Dakota Territory, delegate to the House of Representatives, three terms as mayor of Springfield, Illinois, from 1876
 
Given name
- Jayne Appel (born 1988), basketball player
 - Jayne V. Armstrong (fl. 1996), British botanist
 - Jayne Atkinson (born 1959), English film, theatre and television actress
 - Jayne Baxter, Scottish Labour Party politician
 - Sarah-Jayne Blakemore, Professor of Cognitive Neuroscience at University College London
 - Jayne Brook (born 1960), American actress
 - Jayne Casey (born 1956), English artistic director
 - Jayne Cobb, a character from the television series Firefly
 - Jayne Cortez (1934–2012), African-American poet, activist, small press publisher and spoken-word performance artist
 - Jayne County (born 1947), American performer, musician and actress
 - Katrina Jayne Dimaranan (born 1993), Filipino-American beauty pageant titleholder
 - Sarah Jayne Dunn (born 1981), English actress
 - Jayne Eastwood (born 1946), Canadian actress
 - Jayne Furlong, New Zealand girl abducted in 1993 and murdered
 - Jayne Gackenbach, writer and dream researcher
 - Mary Jayne Gold (1909–1997), American heiress, helped European Jews and intellectuals escape Nazi Germany in 1940-1941
 - Jayne Grayson, a character from the television series Holby City
 - Mary Jayne Harrelson (born 1978), female middle distance runner from the United States
 - Jayne Hayden (born 1968), former operative for the Central Intelligence Agency
 - Jayne Heitmeyer (born 1960), Canadian actress
 - Jayne Hepsibah, milliner
 - David Jayne Hill (1850–1932), American academic, diplomat and author
 - Jayne Houdyshell (born 1953), Tony Award–nominated American theater actress
 - Jayne Hughes, the Deputy High Bailiff and Judicial Officer of the Isle of Man
 - Jayne Irving (born 1956), British TV presenter
 - Jayne Jagot, Australian judge
 - Jayne Fenton Keane, contemporary Australian poet
 - Jayne Kennedy (born 1951), American actress, beauty pageant titleholder and sportscaster
 - Jayne Ann Krentz, née Jayne Castle (born 1948), American writer of romance novels
 - Jayne Lawless (born 1974), English installation artist from Liverpool
 - Jayne Loader (born 1951), American director and writer
 - Jayne Ludlow (born 1979), Welsh football coach and former player
 - Jayne Mansfield (1933–1967), American actress in film, theatre, and television
 - Jayne Marie Mansfield (born 1950), the first child of Jayne Mansfield
 - Jayne McHugh (born 1960), former volleyball player
 - Jayne Meadows (1919–2015), American stage, film and television actress, author and lecturer
 - Jayne Middlemiss (born 1971), English television and radio presenter
 - E. Jayne Mockler, Democratic member of the Wyoming Senate
 - Jayne Modean (born 1958), American model and actress
 - Sarah-Jayne Mulvihill (1973–2006), Flight Lieutenant in the Royal Air Force who died in Iraq
 - Jayne Parsons (born 1962), New Zealand paralympic cyclist
 - Jayne Anne Phillips (born 1952), American novelist and short story writer
 - Jayne Pierson, Welsh fashion designer
 - Jayne Pupek (1962–2010), American poet and fiction writer
 - Jayne Walton Rosen (1917–2010), American entertainer, singer and actress
 - Jayne Sharp (born 1977), English broadcaster
 - Jayne Torvill, OBE (born 1957), British ice dancer
 - Jayne Trcka, amateur female bodybuilder and actress
 - Jayne Tunnicliffe (born 1967), English actress
 - Jayne West, American operatic soprano
 - Emma-Jayne Wilson (born 1981), Sovereign and Eclipse Award-winning jockey in Thoroughbred horse racing
 - Jayne Wisener (born 1987), actress and singer from Northern Ireland
 - Jayne Wrightsman (1919–2019), American philanthropist, fine arts collector widow of Charles B. Wrightsman
 
See also
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