LaCasse or Lacasse (French pronunciation: [lakas]) is a French surname. Notable people with the surname include:
- Alex Lacasse, Canadian pop artist
 - Cloé Lacasse (born 1993), Canadian soccer player
 - Florent Lacasse (born 1981), French middle distance runner
 - Geneviève Lacasse (born 1989), Canadian ice hockey player
 - Josée Lacasse (born 1965), Canadian alpine skier
 - Josée Lacasse (born 1970), Canadian rugby union player
 - Joseph Lacasse (1894–1975), Belgian artist
 - Joseph-Henri-Gustave Lacasse (1890–1953), Canadian journalist, physician and politician
 - Ryan LaCasse (born 1983), American football player
 - Suzanne Lacasse (born 1948), Canadian civil engineer
 
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