Last drop is often an allusion to the proverb "The last drop makes the cup run over". It may also refer to:
- The Last Drop (Leyster), a 1639 painting by Judith Leyster
 - The Last Drop of Water, a 1911 American film by D.W. Griffth
 - "Last Drop", a 2004 song by Kevin Lyttle
 - The Last Drop, a 2006 British-Romanian WWII film by Colin Teague
 - Every Last Drop, a 2008 horror novel by Charlie Huston in the Joe Pitt series
 
See also
- Seneca's phrase "It is not the last drop that empties the water-clock, but all that which previously has flowed out"
 - Final straw (disambiguation)
 
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