Marcuzzi is an Italian surname. Notable people with the surname include:
- Alessia Marcuzzi (born 1972), Italian television personality and actress
 - Angelo Marcuzzi (died 1453), Roman Catholic prelate, Bishop of Telese
 - Michael Marcuzzi, American visual effects artist
 - Santé Marcuzzi (1934–2020), French rower
 - Sebastiano Marcuzzi (1725-1790) Italian abbot from Friuli and writer of texts on religion
 
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