Michael Griffin may refer to:
Sports
- Michael Griffin (American football) (born 1985), football player
- Michael Griffin (footballer) (1887–?), English footballer
- Mike Griffin (outfielder) (1865–1908), American baseball center fielder
- Mike Griffin (pitcher) (born 1957), American baseball pitcher
- Mike Griffin (basketball), American college basketball coach
Others
- Michael D. Griffin (born 1949), former NASA administrator 2005–09 and Under Secretary of Defense for Research and Engineering
- Michael F. Griffin (born 1962), American murdererer of David Gunn
- Michael Griffin (Irish priest) (1892–1920), Irish Roman Catholic priest shot dead during the Anglo-Irish War
- Michael Griffin (Wisconsin politician) (1842–1899), American politician
- Michael Griffin (Indiana politician) (active from 2022), American politician from Indiana
- Michael Griffin (escape artist) (born 1961), American escape artist, magician and illusionist
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