Michael McGuire or Mike McGuire may refer to:
- Michael McGuire (actor) (born 1934), American actor
 - Michael McGuire (author), Australian author and columnist
 - Michael McGuire (politician) (1926–2018), British Labour Party politician
 - Michael J. McGuire (born 1947), environmental engineer and writer
 - Michael T. McGuire (1929–2016), American psychiatrist
 - Mick McGuire (born 1952), English footballer
 - Mick McGuire (general), American major general
 - Mike McGuire (baseball), American college baseball coach
 - Mike McGuire (basketball) (born 1977), American college basketball coach
 - Mike McGuire (politician) (born 1979), American politician
 
See also
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