Ngubane is a South African surname that may refer to
- Ben Ngubane (1941–2021), South African politician
- Menzi Ngubane (born 1964), South African actor
- Mlungisi Ngubane (born 1956), South African football player and coach
- Silindile Ngubane (born 1987), South African football striker
- Sizani Ngubane, South African rural women's rights activist
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