Nicastro may refer to:
- Nicastro, a small town in the province of Catanzaro, in the Calabria region of southern Italy
 
- Francesco Nicastro (born 1991), Italian football forward
 - Fredrik Wikström Nicastro, Svensk film producer and head of feature films at the production company Tre Vänner
 - Michelle Nicastro (1960–2010), American actress and singer
 - Nicholas Nicastro (born 1963), American author and film critic
 - Roberto Nicastro (born 1964), Italian Chairman of the "Good Banks" and Group General Manager of Unicredit
 
- J. McIntyre Machinery, Ltd. v. Nicastro, a 2011 decision by the US Supreme Court about the exercise of court jurisdictions
 
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