SNI may refer to:
Science and technology
- Substitution nucleophilic internal, a chemistry reaction mechanism
 - Swedish Standard Industrial Classification, a Swedish economic classification system
 - Server Name Indication, an extension to the TLS computer networking protocol
 
Companies
- Scripps Networks Interactive, a media company
 - Showtime Networks Inc., an American cable network company
 - Siemens Nixdorf Informationssysteme, a former computer hardware company
 - Société Nationale d'Investissement, a Moroccan conglomerate
 - Sports Network Incorporated, a former American media company
 
Organizations
- National Information Service (Brazil), or Serviço Nacional de Informações, the former name of the Brazilian Intelligence Agency
 - Shelter Now International, a Christian foreign aid organization, based in Germany and historically focused on Pakistan and Afghanistan
 - Sistema Nacional de Investigadores, a Mexican government agency
 - Soviet Naval Infantry
 - Swiss Nanoscience Institute
 
Other uses
- Standar Nasional Indonesia (Indonesian National Standard), formulated by the National Standardization Agency
 
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