Santisteban is a Spanish-language surname. Notable people with the surname include:
- Anna Santisteban (1914–2003), Puerto Rican businesswoman
 - Juan Santisteban (born 1936), Spanish footballer and manager
 - Fernando Silva Santisteban (1929–2006), Peruvian historian, anthropologist, and academic
 
See also
- Santisteban del Puerto, city in the province of Jaén, Spain
 
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