Seneca is a given name and an Italian surname which may refer to:
Given name
- Seneca Lassiter (born 1977), American former middle-distance runner
 - Seneca M. Dorr (1820–1884), American lawyer, judge, politician and President of the Vermont Senate
 - Seneca Paige (1788–1856), American-born businessman and political figure in Canada East
 - Seneca Ray Stoddard (1844–1917), American landscape photographer
 - Seneca Wallace (born 1980), American National Football League quarterback
 
In fiction
- Seneca Beaulac, from the American daytime soap opera Ryan's Hope
 - Seneca Crane, in The Hunger Games novel by Suzanne Collins and the film adaptation
 
Surname
- Seneca the Elder (54 BC – 39 AD), Roman orator and writer, father of the Stoic philosopher Seneca
 - Seneca the Younger (c. 4 BC – AD 65), Roman Stoic philosopher, statesman, and dramatist
 - Isaac Seneca (1874–1945), American football halfback, first Native American selected All-American
 - Joe Seneca (1919-1996), American actor and songwriter
 - Robert Seneca (died 1931), American politician and merchant
 
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