Sickles may refer to:
People
- Carlton R. Sickles (1921–2004), American lawyer and congressman from Maryland
 - Daniel Sickles (1819–1914), American politician and Civil War general
 - Mark D. Sickles (born 1957), American politician
 - Nicholas Sickles (1801–1845), U.S. Representative from New York
 - Noel Sickles (1910–1982), American commercial illustrator and cartoonist
 - Robin Sickles, American economist
 - Teresa Bagioli Sickles (1836–1867), wife of Daniel Sickles
 - William Sickles (1844–1938), American Civil War soldier and Medal of Honor recipient
 
Places in the United States
- Sickles, Oklahoma, an unincorporated community
 - Sickles, an unincorporated community in Hamilton Township, Gratiot County, Michigan
 
See also
- Sickels, another surname
 - Sickle (disambiguation)
 
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