Spotted rattlesnake may refer to:

• Sistrurus miliarius, a.k.a. the pygmy rattlesnake, a venomous pitviper species found in the southeastern United States
• Crotalus pricei, a.k.a. the twin-spotted rattlesnake, a venomous pitviper species found in the United States and Mexico
• Crotalus viridis, a.k.a. the prairie rattlesnake, a venomous pitviper species native to the western United States, southwestern Canada, and northern Mexico