Spyropoulos or Spiropoulos Greek: Σπυρόπουλος is a Greek surname. It may refer to:

• Andrea Spyropoulos, British nurse
• Dimitris Spyropoulos, member of the Greek punk rock band Deus Ex Machina
• Farida Mazar Spyropoulos, birth name of Farida or Little Egypt, a Syrian belly dancer
• Georgia Spiropoulos (born 1965), Greek composer
• Jean Spiropoulos (1896-1972), Greek expert of international law
• Kostas Spiropoulos (born 1952), Greek painter and University Professor
• Nikos Spyropoulos (born 1983), Greek footballer
• Panagiotis Spyropoulos (born 1992), Greek footballer
• Theodore Spyropoulos, Greek archeologist
• Yiannis Spyropoulos (1912-1990), Greek painter