TSM may refer to:
- Taiwan Semiconductor Manufacturing Company, a semiconductor foundry
 - IBM Tivoli Storage Manager, a backup software product
 - Texas Student Media, a student media operation of The University of Texas at Austin
 - Toulouse School of Management, a French management college
 - Trinity School for Ministry, a seminary in Pennsylvania
 - Trapezoidal Shadow Map, a technique for real-time shadow mapping
 - Team service management, a management framework
 - Trusted service manager, a business role in the mobile payment environment
 - Teaching-suggestion-motivation, a test of inventive step and non-obviousness in patent law
 - Superior Military Court (Portuguese: Tribunal Superior Militar), one of the federal courts of Brazil
 - Station code for Tasikmalaya railway station
 
Entertainment
- The Shrinking Man, a 1956 novel
 - The Simpsons Movie, a 2007 film
 - The Suicide Machines, a punk band
 - Toy Story Mania!, a theme park attraction
 - Skull Man, 2 manga and 1 anime series
 
Games
- The Sims Medieval, a 2011 video game
 - Team SoloMid, a professional esports team and gaming community website
 
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