U1, U.I or U-1 may refer to:
Arts and entertainment
- Ultima I: The First Age of Darkness, a 1981 video game
 - Yuvan Shankar Raja (stage name: U1; born 1979), a Tamil musician and film composer
 - U1 Technology, a video game publisher
 - U-1, protagonist of the Gitaroo Man video game
 
Computing and mathematics
- U(1), in abstract algebra, the unitary group of degree one
 - U1, a speed class for Secure Digital (SD) cards
 - Apple U1, a mobile system-on-a-chip
 
Military
- U-1, the USAF and US Military's designation for the De Havilland Canada DHC-3 Otter light transport aircraft
 - U-1, Soviet designation for Avro 504 trainer
 - Multiple German U-boats named U-1
 - Oberursel U.I, an early German aircraft engine
 - HDMS U-1, a Danish submarine
 - SM U-1, an Austro-Hungarian submarine, lead ship of the U-1 class
 
Rail
Locomotives
- LNER Class U1, a 1924 British solitary loco
 - SR U1 class, a class of 2-6-0 locos
 
U-Bahn lines
Other uses
- U1, unemployment figure released by Bureau of Labor Statistics
 - U1 spliceosomal RNA, a small nuclear RNA component of the spliceosome involved in pre-mRNA splicing
 
See also
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