Xo or XO may refer to:
Arts and entertainment
- XO (record label), founded by The Weeknd
 - XO (Elliott Smith album), 1998
 - XO (Leathermouth album), 2009
 - Super Robot Wars XO, a 2006 tactical role-playing video game
 - Xiomara "Xo" Villanueva, a character on Jane the Virgin, an American satirical telenovela
 
Songs
- "XO" (song), 2013, by Beyoncé from her self-titled studio album
 - "XO", 2005, by Fall Out Boy from the album From Under the Cork Tree
 - "XO", 2010, by Mike Posner from the album 31 Minutes to Takeoff
 - "XO", 2015, by The Eden Project
 - "XO", 2022, by girl group Citizen Queen
 - "X.O.", 1996, by Luniz from the film soundtrack Original Gangstas
 - "XO / The Host", 2011, by The Weeknd from his third mixtape Echoes of Silence
 
Businesses
- XO Communications, a telecom company
 - XO Group, a media company
 
Food and drink
- XO sauce, a spicy seafood-based dressing sauce
 - XO (extra old), a grade of cognac liquor
 
Science and technology
- XO Telescope or its exo-planet survey
 - OLPC XO, a laptop produced by the One Laptop per Child association
 - XO sex determination system, a chromosomal system used to designate sex of some species of insects, arachnids, and mammals
- XO, heterogametic male designation under this system
 
 - Turner syndrome, a genetic condition in which one of the sex chromosomes is absent
 - Xanthine oxidase, an enzyme that catalyzes the oxidation of hypoxanthine to xanthine
 - Xylenol orange, a chemical indicator for metal ions, used in titrations
 - Crystal oscillator (deprecated abbreviation: XO), an electronic circuit
 
Other uses
- Executive officer or XO, as in a military or police force
 - Hugs and kisses or XO
 - LTE International Airways's IATA airline code
 
See also
- Chi Omega ("ΧΩ"), a National Panhellenic Conference women's fraternity
 - Executive order (disambiguation), an edict by a member of the executive branch of a government
 - Exo (disambiguation), multiple terms
 - OX (disambiguation)
 - Tic-tac-toe, a game using X's and O's
 - X's and O's (disambiguation)
 - Xbox One (XBO), a video game console by Microsoft
 - XOXO (disambiguation)
 
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