Zamfirescu is a Romanian surname. Notable people with the surname include:
- Duiliu Zamfirescu (1858–1922), novelist, poet, short story writer, lawyer, nationalist politician, journalist, diplomat
- Florin Zamfirescu (born 1949), theatre and film actor and director
- George Mihail Zamfirescu (1898–1939), theatre director and playwright
- Elisa Leonida Zamfirescu (1887–1973), an early woman engineer
- Mihail Zamphirescu (1838–1878), poet
See also
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