A zygote is a fertilized biological cell.
Zygote may also refer to:
- Zygote (album), the first solo album from John Popper
- Zygote (software), a software component of the Android operating system
- Zygote Media Group, a high-end 3D rendering and animation software company
- Zygote in My Coffee, an underground magazine in the United States published 2003–2010
- Zygote (2017), a short SF/horror movie created by Oats Studios
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